Top 5 Veterinary Drug Interactions to Consider in 2018

No matter what 2018 holds, one thing’s for certain: the number of veterinary drug interactions that veterinarians need to consider will only increase.

That’s because there are constantly new drugs hitting the market, new studies being undertaken, and new interactions being discovered. Experts say that the cumulative sum of human knowledge doubles every year or so. Whether or not that’s true, few veterinarians would dispute that the amount of information required for the job seems to constantly increase.

Put another way: there’s a lot to remember.

Don’t be overwhelmed, though. It’s true that, in 2018, veterinary drug interactions will increase in number and complexity. But, using smarter tools can ease the unsustainable burden of memorization.

That’s where VPRCloud comes in.

For now, let’s narrow our field of vision down to the interactions of these five drugs. Here are 5 veterinary drug interactions worth considering in 2018.

1. Marbofloxacin

May interact with: antacids, sucralfate, theophylline, probenecid, aminoglycosides, third generation cephalosporins, extended-spectrum penicillin, clindamycin, nitrofurantoin and cyclosporin.

Marbofloxacin is a fluoroquinolone antibiotic commonly prescribed to treat bacterial infections in animals. It’s often used to treat skin infections, respiratory infections, and urinary tract infections in both dogs and cats.

Aside from the effects of veterinary drug interactions, it may also cause potential side effects including vomiting, diarrhea, and a loss of appetite.

It is also not recommended for young animals, because it can increase the risk of a cartilage injury.

2. Cisapride

May interact with: vitamins and supplements, anticholinergic agents (atropine), cimetidine, ranitidine, anticoagulants, benzodiazepine tranquilizers (such as diazepam [Valium]), ketoconazole, IV miconazole, itraconazole, or troleandomycin, any antibiotics, or antihistamines.

Cisapride is commonly prescribed to stimulate the movement of food through the digestive tract, to treat reflux and enlargement of the esophagus. It may also be used to treat chronic constipation or enlargement of the colon.

Interestingly, the human version of the drug is no longer available in the United States. But, veterinary forms are still in use.

Aside from the effects of veterinary drug interactions, Cisapride may also cause side effects including diarrhea and abdominal cramps.

It is not recommended for pregnant animals.

3. Maropitant Citrate

May interact with: drugs that are highly protein-bound such as phenobarbital, non-steroidal anti-inflammatory drugs and thyroid hormone supplements.

Maropitant citrate is a common medication for suppressing vomiting in dogs. Often, it’s prescribed to relieve motion sickness or to relieve the symptoms of stomach and intestinal problems, infections, or pancreatitis.

While it is a relatively benign drug in terms of potential interactions, it’s important to avoid interactions with highly protein-bound drugs, among others.

Generally, maropitant citrate has few side effects without drug interactions; it may sometimes increase drooling, diarrhea, loss of appetite, or drowsiness. However, these reactions are uncommon.

It is not recommended for pregnant animals.

4. Alprazolam

May interact with: vitamins, supplements, cimetidine, erythromycin, isoniazid, ketoconazole, propranolol, and valproic acid, or other central nervous system depressants (e.g., narcotics, barbiturates), digoxin, and rifampin.

Alprazolam is the veterinary variant of the human drug Xanax. It’s used to treat behavior disorders in cats and dogs – most often, those behaviors associated with high levels of anxiety.

Most commonly, the side effects associated with alprazolam are increased drowsiness or sedation. However, rarely, other behavioral changes can occur (such as over excitement or increased aggression).

Alprazolam is not recommended for pregnant animals.

5. Benazepril

May interact with: vitamins and supplements, diuretics (e.g. Lasix, Salix), other vasodilators, non-steroidal anti-inflammatory drugs (NSAIDs) e.g., aspirin, etodolac (EtoGesic), carprofen (Novox or Rimadyl), meloxicam (Metacam, firocoxib (Previcox), tepoxalin (Zubrin), or deracoxib (Deramaxx).

Benazepril is an ACE inhibitor, primarily used to treat conditions such as heart failure and high blood pressure by dilating veins and decreasing fluid retention in animals. It may also be used to treat some forms of kidney disease in dogs and cats.

Aside from veterinary drug interactions, side effects may include lack of appetite, vomiting, and diarrhea. Rarely, benazepril may cause low blood pressure or abnormally high potassium levels. In general, side effects from benazepril are uncommon.

It should be used with caution in animals with very low blood sodium levels, and it’s not for use in animals with lupus or blood abnormalities, pregnant animals, or animals with liver disease.

A Better Way to Remember Veterinary Drug Interactions

If you can remember the interactions of these five drugs in 2018, you’ll be off to a good start. But even that may be a tall task, unless you’re gifted with a photographic memory.

Fortunately, there’s a better way to access veterinary drug interaction knowledge: VPR Cloud.

VPR Cloud is an online and comprehensive veterinary pharmacy reference that provides constantly updated drug information. No matter what changes occur in 2018, VPR Cloud allows veterinarians to stay updated on all of the potential and major veterinary drug interactions with each prescription.

It even provides printable client information sheets, to make passing knowledge onto the client as easy as possible, too.

The amount of veterinary information that veterinarians need to know will only increase. In 2018, there will certainly be new veterinary drug interactions to consider. Fortunately, veterinarians can rest easy, knowing that the burden of memorization is unnecessary thanks to VPRCloud.

Get in touch to start your free trial today.